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While both interventions derive from the growth hormone molecule, their safety profiles differ substantially due to AOD-9604s selective mechanism that avoids traditional GH receptor activation

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The effects of Glu are mediated by ionotropic glutamate receptors (iGluRs), ligand-gated ion channels which are categorized into four distinct subclasses based on their selective agonists: -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), kainate receptors (KARs), N -methyl-D-aspartic acid receptors (NMDARs), and receptors (GluDs) (Hansen et al., 2021) (Figure 1A)

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