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Manufacturers may fortify certain foods, such as cereals, with the synthetic form of vitamin B12

The results are temporary but should last approximately four to six months

Repletion of vitamin B12 may improve response in patients resistant to antidepressants (10) , and in older adults with major depression, long-term supplementation with a combination of B12, B6, and folic acid enhanced antidepressant treatment efficacy (40)

And 3.2% of people aged 50-plus are B12 deficient, according to the Centers for Disease Control and Prevention (CDC)

Improper aseptic technique can introduce bacteria that may overwhelm the preservative, leading to serious infection if contaminated solution is administered