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doi: 10.1002/art.40896 36 n-3
Concentrations of 8-oxo-dG within a cell are a measurement of oxidative stress
Finally, folate-mediated one carbon metabolism, in which its activity is induced in LPS-activated Ms (54) also contributes to the regeneration of reduced NADPH levels, with serine and glycine as the major carbon sources of this pathway
GLUTATHIONE IMPORT TO MITOCHONDRIA As indicated above, despite the fact that the concentration of mGSH is high, GSH is not synthesized de novo in the mitochondrial matrix, as this organelle lacks the enzymes required for GSH synthesis
For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34
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