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Lycopene is one of the most powerful antioxidants among carotenoids, as it activates the WNT/-catenin and ERK1/2 pathways, upregulating RUNX2, ALP, and type I collagen, while downregulating RANKL

Huang et al., 2015), if properly accomplished, may be the principle largely generalized (see Skin Wounds )

8-OHdG 8-hydroxy-2'-deoxyguanosine AMH anti-Mllerian hormone ART assisted reproductive technology ASRM American Society of Reproductive Medicine ATP adenosine triphosphate CAT catalase CCS comprehensive chromosomal screening FISH fluorescence in situ hybridization FF follicular fluid G6PD glucose-6-phosphate dehydrogenase GPx glutathione peroxidase GR glutathione reductase GSH glutathione GST glutathione S-transferase H 2 O 2 hydrogen peroxide ICSI intracytoplasmic sperm injection IL-6 interleukin 6 IVF in vitro fertilization LC L-carnitine MDA malondialdehyde mtDNA mitochondrial DNA NAC N-acetyl cysteine O superoxide anion radical OH hydroxyl radical PF peritoneal fluid PGS preimplantation genetic selection PGT-A preimplantation genetic testing for aneuploidy PN pronucleus ROS reactive oxygen species SOD superoxide dismutase TNF tumor necrosis factor XXO xanthine oxidase

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It loses its glow and turns out saggy, wrinkled, and pigmented