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The molecule has two asymmetric carbons at the 3 and 3 positions on the -ionone rings, giving rise to three optical stereoisomers: (3S,3S), (3R,3R), and the meso form (3R,3S)

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Folinic acid (2 mg/kg/day, max 50 mg/day) produced significantly greater improvements in standardized verbal communication scores and several adaptive and behavioral subscales compared with placebo, with a stronger effect on children ( Furthermore, a placebo-controlled randomized trial evaluated the efficacy of folinic acid (5 mg twice daily) for 12 weeks in 19 children aged 310 years (sex distribution not reported) with ASD diagnosed by ADOS, without genetic syndromes, major medical comorbidities, or treatments affecting folate metabolism