Similarly, trametinib (a MEK inhibitor) enhances the transcription of ferritin heavy chain (FTH1) and ferritin light chain (FTL) and promotes ferritinophagy through NCOA4 while reducing ferroportin expression, thereby increasing intracellular iron levels and ultimately triggering ferroptosis in PDAC cells [22]
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Quercetin modulates the interplay between DNMT gene expression, oxidative stress, and trace elements in DHEA-induced polycystic ovary syndrome rat model
By ensuring that these immune cells are functioning optimally, glutathione not only aids in detoxification but also enhances the body's ability to respond to pathogens, thereby supporting overall health and resilience against diseases
Elevated levels signal liver damage, heart problems or other conditions
doi: 10.1038/srep16423 30 EbrahimiM.MousaviS