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When SAH accumulates, it inhibits many methyltransferases and can reduce effective methylation even when folate, methionine or SAM are available

Most of the methyl groups used for conjugation of toxins come from s-adenosylmethionine (SAMe)

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All clinical decisions regarding patient eligibility, dosing, monitoring, and treatment should be made by a licensed healthcare provider based on the individual patients clinical presentation, medical history, and applicable standard of care

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Determination of some kinetic and characteristic properties of glutathione S-transferase from bovine erythrocytes