The 2024 Vanderbilt finding that a diastolic BP increase greater than 17 mmHg during late phase 2 of the Valsalva maneuver identifies patients with high sympathetic nerve activity is a simpler, office-based alternative to plasma catecholamine testing
GLP-1 (glucagon-like peptide-1) stimulates insulin in response to elevated blood glucose, reduces glucagon output, slows gastric emptying, and signals fullness to the brain
Structure-activity relationship of pharmacophores and toxicophores: the need for clinical strategy
Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A multicentre, randomised, double-blind, placebo-controlled study
The result, in the landmark STEP clinical trials published in The New England Journal of Medicine , was an average body weight reduction of approximately 15% over 68 weeks a level of efficacy previously only seen with bariatric surgery
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