They should be administered by trained clinicians who screen properly first
Communication is great also
BBB opening can increase the local concentration of therapeutic agents in the brain without damaging normal tissue, and via FUS-BBB opening to enhance CNS penetration of AD-treated therapeutic agents is an attractive approach

A clinical study published in the New England Journal of Medicine in 2024 (4) showed that, in people with excess fatty liver with mild to moderate fibrosis , administration of semaglutide once a week for 240 weeks was correlated with: improvement in liver composition and inflammation without worsening of fibrosis in more than 60% of cases, compared with approximately 34% of subjects on placebo reduction in scar tissue without worsening of steatohepatitis in more than 36% of patients, compared with around 22% of those on placebo resolution of steatohepatitis with a reduction in fibrosis in 32.7% of patients, compared with 16.1% in the placebo group average reduction in body weight of 10.5%, compared with just 2.0% on placebo The mechanisms that could explain these results From a medical point of view, these effects on liver health could be explained by several complementary mechanisms: a general reduction in body fat , particularly visceral fat in the abdomen and liver, a criterion often associated with improvements in liver parameters (5) a reduction in oxidative stress , known to damage liver cells (6) Although potentially interesting for supporting liver function , GLP-1 agonists are drug treatments that can have side effects (7)

That said, safety is generally a function of health and dosage, so it is important that you speak with a registered healthcare provider before beginning the therapy to rule out any contraindications and get ongoing evaluation of your progress
This observation led them to speculate that GLP-1 analogs might possess distinct neurotrophic properties and exert protective effects specifically on the nerve