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( Add-on Trials As both DPP-4 inhibitors and GLP-1RA work through enhancing GLP-1 activity, one might predict that combining the two classes would not be ideal

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Strong appetite suppression: Participants reported eating less naturally due to reduced hunger and increased satiety

As one 2026 review put it, the original composition-of-matter patents "have likely expired reducing the commercial exclusivity that typically incentivizes industry-sponsored Phase II and III development" [13]

& Tschp, M