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It is not a toxicity concern but an efficacy consideration

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According to NICE Technology Appraisal 875, Wegovy is recommended only within a specialist weight management service for adults with a body mass index (BMI) of at least 35 kg/m and at least one weight-related comorbidity

doi: 10.3389/fmicb.2018.02297 103 SpadoniIZagatoEBertocchiAPaolinelliRHotEDi SabatinoAet al