Lamers F, Milaneschi Y, Vinkers CH, Schoevers RA, Giltay EJ, Penninx BWJH
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1 Background: The STEP UP Phase 3b Trial The STEP UP trial was a randomized, double-blind, phase 3b study designed to evaluate the efficacy and safety of a higher weekly dose of subcutaneous semaglutide (7.2 mg) compared to the currently approved 2.4 mg dose
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MD simulations demonstrated that, compared to the wild-type PV2 (WT), PV2-C23pAcF exhibited a significantly higher total number of hydrogen bonds in replica 1approximately 80 morewhereas PV2-C96pAcF showed only a slight increase relative to WT (Fig