Salicylic acid is perfect for targeted use, like applying to the T-zone on combination skin to keep pores clear without over-drying the cheeks. You can also try a salicylic acid facial cleanser to keep oil and breakouts at bay
Those drugs are complex peptides that must be injected because they cannot survive the digestive system intact, and they cannot penetrate the skin in meaningful amounts either (6)
Mice studies do show that they live longer when given supplemental melatonin over the course of their lives, starting in adulthood.[ref][ref][ref][ref] Animal studies also show that melatonin supplementation (beginning in middle to old age) prevents the decrease in bone mass associated with aging.[ref] It also increases mitochondrial function.[ref] Melatonin is necessary to reap the benefits of exercise when aging.[ref] Supplemental melatonin also doubles insulin sensitivity in older animals.[ref] We dont do human studies on chronic calorie restriction to extend lifespan nor have there been long-term studies in humans on supplemental melatonin for fifty-plus years to know the effect
This schedule helps maximize the benefits while preventing your body from becoming too accustomed to the peptides
Chia K, Klingseisen A, Sieger D, Priller J (2022) Zebrafish as a model organism for neurodegenerative disease
7e) at 12 days post-infection