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To dissect the actions of AR signaling in a range of cell types that contribute to the process of fracture healing, we generated genetically engineered mice in which the AR gene was specifically ablated in periosteal cells (AR -/Y ;Prrx1::Cre mice) or chondrocytes (AR -/Y ;Col-2::Cre mice), and created a closed transverse femoral fracture to compare the bone healing with that in AR flox/Y mice

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Bahr, who is prediabetic and has several other health conditions, said she was initially hesitant to use a weight-loss drug because she didn't want to be seen as "taking the easy way out" and was worried about potential side effects

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also in Contrave)