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Three monomers of GSTO1 were present in the asymmetric unit of the GSTO1 C1-27 and GSTO1 C4-10 crystals, while a dimer was present in the GSTO1 C1-31 crystal

Cytochromes P450 2E1 (CYP2E1) and 3A4 (CYP3A4) convert paracetamol to a highly-reactive intermediary metabolite, N-acetyl-p-benzo-quinone imine (NAPQI).[31][32][33] Under normal conditions, NAPQI is detoxified by conjugation with glutathione

Cell nuclei were stained with DAPI

Molecular docking demonstrated a hydrogen bond-based interaction between berberine and Arg-141 residue, whereas molecular dynamics simulation proposed the establishment of a stable conformation ( 2.1.5 Benzodiazepines Benzodiazepines are among the new psychoactive substances (NPS) that are recently emerging in large numbers

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