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Many of the participants lost more than 20% of their weight
The STEP 4 trial demonstrated that continuous weekly dosing was necessary to maintain weight loss, and discontinuation resulted in weight regain
The long-term weight loss effect of GLP-1RAs has also been validated in a recent large-scale clinical trial, which reported a weight loss up to 20.9% after 72-week treatment of tirzepatide [22]
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