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Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) and Vision Loss A serious eye condition involving reduced blood flow to the optic nerve, which may result in sudden and permanent vision impairment
Because these compounds are naturally occurring peptides with restricted patentability, opportunities for intellectual property protection and industry-sponsored development are limitedposing substantial barriers to the resource-intensive clinical investigations required to confirm therapeutic efficacy and long-term safety
These include cysteine, glycine, and glutamic acid
On February 7, 2024, Innovent announced that the New Drug Application (NDA) for mazdutide, a glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) dual agonist, had been accepted by the Center for Drug Evaluation (CDE) of the National Medical Products Administration (NMPA) of China, for chronic weight management in adults with obesity or overweight
The company stated it is working diligently to address concerns
Side Effects Common side effects Nausea Vomiting Diarrhea Stomach pain Loss of appetite Serious but less common side effects Risk of pancreatitis Gallbladder issues (gallstones, inflammation) Kidney problems (from dehydration due to vomiting/diarrhea) Potential increased risk of thyroid C-cell tumors (based on animal studies) Patients should report severe or unusual symptoms to their healthcare provider immediately
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