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In addition to biological activity as an essential intracellular antioxidant, GSH facilitates the clearance of metabolic waste via GSH- S -transferases and may function as a neuropeptide
Our evaluation included several trials that showed decreases in inflammatory markers combined with improvements in surrogate cardiovascular markers such as flow-mediated dilation, epicardial adipose tissue, carotid intima-media thickness, and endothelial cell biomarkers ( These anti-inflammatory mechanisms may play a significant role in mediating the long-term cardiovascular effects of GLP-1 RAs shown in outcome trials
Although normal electron transport in mitochondria involves four-electron reduction of O 2 to water, partial reduction reactions occur under physiological conditions, causing release of superoxide anion and hydrogen peroxide (H 2 O 2 )
Smith SA, Ogawa SA, Chau L, Whelan KA, Hamilton KE, Chen J, et al
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