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A systematic review and meta-analysis of 12 randomized controlled trials (RCTs) involving 11 459 overweight or obese adults without diabetes demonstrated that GLP-1 receptor agonists significantly reduced body weight, alongside notable improvements in glycemic control, lipid levels, and blood pressure
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Chronic semaglutide treatment promotes changes in substrate oxidation Consistent with the composition of the 60% HFD and feeding patterns, the respiratory exchange ratio (RER) in vehicle-treated mice vacillated steadily between 0.75 and 0.8, indicative of greater lipid oxidation relative to carbohydrate oxidation ( Figure 4A-B )
PMID: 22486766
& Diekman, B
J Endocrinol (2013) 219(1):5968.10.1530/JOE-13-0146 27 SunHXLuNLuoXZhaoLLiuJM
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