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However, the biotransformation of selenium into selenodiglutathione (GSSeSG) inside the vacuole does not contribute toward the reduction of its toxicity

Secondly, FAPa + fibroblasts are almost undetectable in non-inflammatory conditions, while they significantly increase in inflamed synovial membranes, and the synovial inflammatory milieu tends to promote ferroptosis and lipid ROS production, and induction of ferroptosis is effective in reducing the number of FLSs and thereby improving RA

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