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Finally, there is some conflicting evidence about the effect of GLP-1RA therapy and muscle loss
PMCID: PMC6887906
Individuals with a personal or family history of medullary thyroid carcinoma (MTC): GLP-1 medications have been linked to an increased risk of MTC in animal studies
For obesity trials, however, it can miss a crucial question: Where are the patients actually located
Additionally, clinical trials have shown that GLP-1RAs improve liver histology in patients with MASLD and NASH, as evidenced by reductions in liver fat and inflammation (Gu et al., 2023)
By performing a GWAS in the tirzepatide-treated population alone (Supplementary Table 12), we identified an association between the vomiting side effect and GIPR (rs71338792, P = 4.2 10 9 , odds ratio = 1.84
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