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In 2018 Zheng and colleagues compared the efficacy of SGLT-2i, GLP-1 agonists, and DPP4i on mortality and cardiovascular end points using a network meta-analysis of 236 trials with 176 310 participants, finding that SGLT-2 inhibitors were associated with reduction in all MIs [HR 0.86 (95% CI 0.770.97)] and nonfatal MIs [HR 0.84 (95% CI 0.720.98)] compared with the control groups (Zheng et al., 2018)

doi: 10.7759/cureus.45181

Considering the increasing numbers of PTC cases, the expression of GLP-1R in a subset of PTCs is likely to be more significant than the possibility of C cell neoplasms

While these medications are mainly associated with improved insulin sensitivity and weight loss, researchers are learning that the benefits of these GLP-1 drugs may go well beyond these effects

It helps the body handle glucose, supports movement, maintains strength, and contributes to a healthier resting metabolic rate

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