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Without adequate levels of carnitine, these long-chain fats cannot efficiently enter the mitochondria to be utilized as fuel

HF may cause kidney dysfunction through multiple mechanisms, including neurohormonal activation, inflammation and oxidative stress, with consequent reductions in renal perfusion and augmentation of renal venous pressure

ii) Utilizing the steric hindrance conferred by dimerization reduces protease access to the active site and significantly improving stability against proteases 49,50

Essa, N., Farrag, B., Kamel, A

doi:10.1016/S0140-6736(08)60073-2