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Reviews typically cant control for confounders (diet changes, exercise, stimulant intake, sleep, stress, or other supplements), and negative experiences are often underreported
Selenium supplementation and oxidative stress: A Review
The brain is well adapted to neutralize oxidative injury by maintaining a high steady-state concentration of small-molecule intracellular antioxidants including glutathione in astrocytes and ascorbic acid in neurons
PMID 25022318
Plenty of natural substances are toxic
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