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Acute measurements that will require more extensive study are needed before any meaningful conclusion can be made regarding the long-term prospects for combination therapy as mixture or for a single molecule with integrated dual agonism

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Neuroimage 85 , 498507 (2014)

"Optimized tri-agonist design achieves superior metabolic outcomes in preclinical models." Molecular Metabolism

These changes interact with sleep in important ways that deserve attention for optimal results

Rosiglitazone inhibited anaplastic TC cell proliferation in vitro and increased the effect of the chemotherapy paclitaxel (Copland et al.)