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In fact, people with vitamin B12 levels on the lower side of normal performed worse on memory tests than those with high-normal levels in a study in The American Journal of Clinical Nutrition (5)

The main role of vitamin E in the skin is to prevent damage from free radicals and reactive oxygen species which are highly reactive chemicals that contain oxygen that react easily with other molecules

There will always be people who are at high risk of raised homocysteine, but the only way to find out definitively is to perform a validated homocysteine test, and then monitor levels regularly going forwards

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[1] Le Truc Nguyen, et al

PubMed: 12750433 TB-4 wound healing dermal repair acceleration with TB-4 in wound models: Malinda KM et al