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10.3390/cancers13194988 47 HirakawaT.YashiroM.DoiY.KinoshitaH.MorisakiT.FukuokaT.et al (2016)

GLP-1 and Fatty Liver Disease (NAFLD/NASH) GLP-1RAs show promising benefits in: Hepatic steatosis reduction Weight loss-mediated liver improvement Improved insulin resistance Reduced inflammation These agents are likely to become central therapies in metabolic-associated steatotic liver disease (MASLD)

"Dynamic dozen for the decade"

A bright future for GLP-1 pills There is a fast-growing bank of evidence that GLP-1s have benefits beyond weight loss, but these two studies demonstrate that the pills are likely to change the landscape even further

Peer review Peer review information Nature Reviews Rheumatology thanks Helena Marzo-Ortega, who co-reviewed with Jacob Williams

SSIEM 2018 sponsored satellite symposium 6: optimising long-term outcomes of patients with propionic and methylmalonic acidaemias