Methionine Methionine, an important amino acid containing sulfur, undergoes transmethylation processes to produce metabolic byproducts such S-adenosylmethionine (SAM) and homocysteine
However, paradoxically, excessive Fe accumulation can trigger intracellular iron overload, promoting ferroptosis
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Feb 2023;25(2):407-416
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We propose that the requirement of two distinct glutathione interaction sites for the efficient reduction of glutathionylated disulfide substrates explains the deviating structurefunction relationships, activities and substrate preferences of different glutaredoxin subfamilies as well as thioredoxins