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Studies on bioactive peptides report reduced joint discomfort and improved mobility compared to control groups, although results vary by compound

Fewer degranulation events mean less release of all inflammatory mediators, not just histamine

Sensitive patients may react poorly: Individuals with MCAS, histamine intolerance, CIRS, medication sensitivity, neurological sensitivity, or high inflammatory burden may need extra caution, as it can cause overstimulation

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Comparative effectiveness research with established therapies would help determine the relative benefits and risks of these peptides compared to current standard treatments and would inform evidence-based treatment decisions

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