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Similarly, a rodent model of surgical trauma showed a 19-fold rise in plasma mtDNA within minutes of incision (34)

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and Vander Heiden, M.G

Its unique feature is selectivity : in the defining study it triggered no relevant rise in ACTH, cortisol or prolactin even at more than 200 times the GH ED50, unlike the older GHRP-6 or GHRP-2 [PMID 9849822]

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In animal and cell studies it is associated with upregulation of repair-related growth-factor and angiogenic signalling (for example VEGF-linked pathways), collagen and extracellular-matrix (ECM) remodelling, and modulation of inflammation, which underlies research interest in connective-tissue and gut-lining recovery