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When they bind to their receptors, JAK proteins are recruited intracellularly, dimerized and activated through autophosphorylation
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Receptor desensitization is less of a concern here than intuition might suggest
Surface plasmon resonance (SPR) analysis SPR measurements were performed using a WeSPR OneAuto instrument (XLEMENT) maintained at 25 C
However, significant cost, access, and sustainability challenges must be addressed for broader population-level impact
Mine was all in silico and all that stuff
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