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What the body does to drugs APPARENT VOLUME OF DISTRIBUTION BIOAVAILABILITY CLEARANCE ELIMINATION HALF LIFE LOADING DOSE MAINTENANCE DOSE CLINICAL CORRELATES: Drugs that are significantly metabolized with one pass through the liver (and have a large extraction ratio) will have a low bioavailability when given orally

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doi: 10.3389/fphar.2024.1439536 Received 13 June 2024 Accepted 19 September 2024 Published 08 October 2024 Volume 15 - 2024 Edited by Karim Hosni, Institut National de Recherche et d'Analyse Physico-Chimique (INRAP), Tunisia Reviewed by Lourdes Franco, Faculty of Medicine.University of Extremadura, Spain Jolanta Orze-Gryglewska, University of Gdansk, Poland Updates Copyright 2024 Mu, Qu, Yin, Wang, Liu and Liu

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Similarly, GHK-Cu is tested for its potential toxic effects