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Since D2HG and L2HG are indistinguishable in standard LC-MS, to determine which 2HG enantiomer(s) is affected, we adapted a chiral N-(p-toluenesulfonyl)-L-phenylalanyl chloride (TSPC) derivation followed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis 24,40

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In Vitro Cell Model Systems Myocyte Cell Culture Models Primary myocyte cultures and established myoblast cell lines serve as standard experimental models for IGF-1 LR3 receptor pharmacology studies

Mitochondria are important components of cell metabolism, and the changes in mitochondrial outer membrane permeability are closely related to apoptosis

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