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A possible reason for the consumption of GSH during oxidative stress is its conversion into oxidized form, which can be conjugated with protein thiol groups to form mixed disulphides (PSSG), via a process called protein-S-thiolation 59
PMID 37255827
A deficiency may lead to a wide range of symptoms, including: Ongoing fatigue or low energy Brain fog or difficulty concentrating Low mood or irritability Pale skin or a yellow tinge Tingling or numbness in the hands and feet Shortness of breath Dizziness or feeling faint Mouth ulcers or sore tongue Blurred vision Some of these symptoms may also be caused by iron deficiency
Since ROS induce tissue damage, thrombosis and red blood cell dysfunction that contribute to COVID-19 disease severity, administration of free radical scavengers could be beneficial for the most vulnerable patients (Laforge et al., 2020)
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