This confusion is only the surface
In preclinical models, GIP has been shown to decrease food intake and increase energy expenditure therefore resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids. Incretin hormones are released whenever food is consumed
doi: 10.21037/atm-21-4162 25 FDA
Efficacy and safety of oral semaglutide in Japanese patients with type 2 diabetes: A post hoc subgroup analysis of the PIONEER 1, 3, 4 and 8 trials
however, its side effects should not be ignored
No new safety signals appeared between weeks 24 and 48, suggesting the medication does not cause delayed-onset problems during the first year of use