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When used together, they are often referred to as a growth hormone-releasing hormone (GHRH) analog and a growth hormone secretagogue combination
Microbiome (2015) 3:23
Fischer et al., 2004
Chest 134(6), 2008
Diabetes Care 47 , 17181730 (2024)
Upregulated: collagen synthesis genes (COL1A1, COL3A1), antioxidant genes (SOD1, SOD3), DNA repair genes (GADD45A) Downregulated: inflammatory cytokines (IL-6, TNF-), metalloproteinases (MMP-2, MMP-9), pro-fibrotic mediators Net effect: shift from tissue destruction and inflammation toward repair and remodeling This breadth of gene modulation is unusual for a single tripeptide and has generated significant research interest in fields ranging from dermatology to neuroscience
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