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Is 10-22% weight loss realistic for someone who is mildly overweight
Seek medical advice if urine changes are accompanied by pain, burning, sweet or fruity smell, blood, or signs of dehydration
SURMOUNT Trial Data, What Researchers Are Working From The pivotal SURMOUNT-1 trial (Jastreboff et al., NEJM 2022, NCT04184622) enrolled 2,539 adults with obesity (no type 2 diabetes) over 72 weeks
Future directions Future research directions for the use of GLP-1R agonists in the treatment of pain and headache disorders should focus on conducting human trials to evaluate their efficacy and safety, particularly in individuals with comorbid obesity [60]
No separate reconstitution is required
Semaglutide has the strongest evidence base for cardiovascular protection
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