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Key safety observations from available trial data include: Elevated resting heart rate in a dose-dependent manner Gastrointestinal adverse effects (nausea, vomiting, diarrhoea) as the most common side effects, consistent with the GLP-1 receptor agonist class [1] [3] No clinically significant QT interval prolongation was reported in available data, though the extent of formal thorough QT assessment has not been fully detailed in published sources

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Severe allergic reaction: Hypersensitivity reactions were reported in 313% of retatrutidemost were mild, but serious reactions are possible with any injectable medication

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There were a roughly equal number of men and women eligible for semaglutide and the typical patient averaged just over 50 years of age, the study authors said

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