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4 Hyperandrogenism, ovulatory function, and fertility outcomes: a reproductive perspective 4.1 Remodeling of the androgen profile and endocrine homeostasis Hyperandrogenism is a hallmark phenotype of PCOS, serving as the link between metabolic derangement and ovulatory dysfunction via the insulinovaryhepatic SHBG axis
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Neuropharmacology 131 , 282290, (2018)
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Investigacin Estudios publicados
In turn, the impairment in -oxidation can shift the metabolism of VPA toward predominantly peroxisomal -oxidation, resulting in excessive production and accumulation of -oxidation products, including 4-en-VPA a metabolite that is incriminated in VPA-induced hepatotoxicity
