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Important safety considerations include: Risk of acute pancreatitis: urgent medical review needed for severe, persistent abdominal pain (with or without back pain) Gallbladder disorders: seek medical advice for symptoms of gallstones (right upper abdominal pain, nausea) Diabetic retinopathy complications: particularly with semaglutide in those with pre-existing retinopathy Hypoglycaemia: risk is low unless combined with insulin or sulfonylureas, which may require dose adjustment Reports of mood changes and suicidal ideation in patients taking GLP-1 receptor agonists are being monitored by regulatory authorities

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However, oral semaglutide (Rybelsus) increases thyroxine exposure and requires thyroid function monitoring when used with levothyroxine, with careful attention to timing of administration

Compounded semaglutide costs far less than the name brands that have the same active ingredient

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