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Captopril, an angiotensin-converting enzyme inhibitor, is widely used in clinical practice to treat hypertension, MI, and congestive heart failure and is effective in attenuating left ventricular (LV) dilatation, ameliorating LV ejection fraction and improving cardiovascular morbidity and mortality [237, 238]

SARS-CoV-2 spike glycoprotein binds TLR4 and activates TLR4 signaling increasing cell surface expression of ACE2 facilitating entry (Aboudounya and Heads, 2021)

Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press

a systematic review and meta-analysis of clinical outcomes