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Curr Diab Rep 15(6):36

Yet glucagon also has broader metabolic actions

However, one of the most important limitations is heterogeneity of the study populations, including disease type, tolerance to treatment, dose of DHA and EPA, timing and duration of DHA and EPA supply, EPA to DHA ratio, initial EPA and DHA status, intake of other nutrients such as vitamins, clinical status, and concomitant use with medications

Targeting this axis may therefore represent a promising strategy to normalize TRP-KYN balance and mitigate depressive symptom burden in MDD

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The relevance of targeting the JAK-STAT pathway to clinical benefit is not currently known