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[6] This enzyme utilizes and stabilizes an acylphosphate intermediate to later perform a favorable nucleophilic attack of glycine

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PMID: 261 KumarSMathewSOAharwalRPTulliHSMohanCDSethiGet al

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Research dose/evidence: Some cosmetic studies show Acmella extract (the source of spilanthol) improves wrinkle appearance, but there are fewer large clinical trials than for retinoids or peptides (there never are with botanical extracts)

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In vivo studies have shown that GHK-Cu accelerates wound healing in various models, including scald wounds in mice, by enhancing angiogenesis and shortening healing time 4

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