In a recent RCT, ertugliflozin improved left ventricular global longitudinal strain in people with type 2 diabetes mellitus and pre-HF, effects associated with increased ACE2 and angiotensin (17) levels, suggesting a potential underlying mechanisms [91]
PMID 6420106
anti-drug antibodies in about 51% (diabetes) to 64.5% (obesity) of users with no effect on clearance, weight, or HbA1c: FDA Mounjaro NDA 215866 label and Summary Review
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