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In patients with type 2 diabetes, the TRANSCEND-T2D-1 trial (published in The Lancet, March 2026) showed HbA1c reductions of 1.72.0 percentage points with 11.516.8% weight loss over 40 weeks, alongside a distinctive dysesthesia signal in a minority of patients that clinicians should watch for

Yes, for the most part

Nature Chemical Biology , 19 (12), 15401550

This is particularly relevant when we consider GSH pathways, as well as their transcriptional regulator Nrf2, for proliferation, survival and function of T cells, B cells and macrophages (Muri and Kopf, 2021)

Unsure if you need an IV for B12

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP