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In the RT-PCR assay, a significant reduction in bone formation capacity was observed subsequent to the loosening of the prosthesis (Fig

Sustained signaling can come with a different side effect profile, including more potential for fluid retention and other growth hormone-related effects

2017 Cell study used 5 mg/kg intraperitoneal injection three times per week in aged mice, with treatment periods of several weeks the three-times-weekly dosing suggests the peptide maintains sufficient functional concentrations for at least 48-72 hours per dose (PMID: 28340339)

Monitoring should include assessment of age, baseline health, coexisting conditions, lifestyle, and concurrent drugs

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