Molecular model
Increasing soluble fibre : Foods such as oats, flaxseeds, lentils, and beans absorb water and form a gel in the gut
This helps to reduce the chance of side effects such as nausea, vomiting, diarrhoea, constipation, or stomach discomfort
As a GLP-1 receptor agonist, it targets receptors in your body, including in your pancreas, that are responsible for regulating how full you feel after a meal, and it slows the rate at which food leaves your stomach.24 The result is that youre likely to eat less than you normally would, so you avoid the excess calories that your body would otherwise store as fat
FDA disclaimer These statements have not been evaluated by the Food and Drug Administration

Therefore, the SGLT2-i induced elevated ANG II levels could act through AT2R resulting in vasodilation, sodium excretion, antiproliferative and anti-inflammation effects ( In addition, it has also been observed a SGLT2-i induced ACE2/ANG(1-7) pathway activation that may play a role in cardioprotection by competing with ANG II and AT1R ( Furthermore, the SGLT2-i hybrid diuretic effect, which combines natriuresis and osmotic diuresis, might also have cardioprotective properties leading to preload and myocardial stretch reduction (the diuretic hypothesis) ( Therefore, SGLT2-i diuretic properties show a major advantage compared to thiazides and thiazides-like diuretics, which act on the Na + CL - -cotransporter in the distal convoluted tubule, or loop diuretics, which block the Na-K-2Cl co-transporter of both the Henle loop and the macula densa, making the macula insensitive to the increased tubular sodium coming from the Henle loop