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A few of the most significant contributors to NAD+ depletion include: CD38: An enzyme that breaks down NAD+ and becomes more active with age, especially in response to inflammation

One study, for instance, notes that people who are overweight or obese appear to have lower levels of vitamin B12 than those with a body mass index (BMI) that falls within the range considered to be normal. People who took vitamin B12 supplements of their own volition gained between 2.5 and 17 fewer pounds (1.27.7 kg) over ten years compared to those who did not take any form of supplementation with this vitamin

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