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Am J Physiol Lung Cell Mol Physiol 283: 766-776

The charge state of every ionizable group -amino (pKa ~9), -carboxyl (pKa ~2), and each side chain is determined by the Henderson-Hasselbalch equation and the 2 rule

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Oily skin might prefer lighter cream textures, whilst dry skin can handle richer, more emollient formulas

It may be higher in metropolitan cities than in small towns