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High doses of vitamin C or iron can exacerbate oxidative stress [15]

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This resulted in differing numbers of patients influencing either end of the KaplanMeier survival curves and the possibility that the behavior of the patients at the beginning of the analysis may have differed from that of the patients nearer the end of the analysis

Informed and written consent was then obtained from the Chef de zone/Mdecin de zone, who represents the interests of the ministry of health and individuals in the study population